Hivent EM/Hivent DS/Hivent Plus

Hivent EM/Hivent DS Salbutamol sulfate Hivent Plus per 2.5 mL Salbutamol 2.5 mg, ipratropium Br 500 mcg

Hivent EM Symptomatic relief of bronchospasm in obstructive airway diseases eg, bronchial asthma, emphysema & chronic bronchitis. Hivent Plus Management of chronic reversible airway obstructions eg, asthma & chronic bronchitis. Patients w/ COPD on regular inhaled bronchodilator who continue to have evidence of bronchospasm & who require a 2nd bronchodilator.

Hivent EM 2.5-5 mg via nebulizer to be repeated up to qid. Hivent DS by wet inhalation 2.5-5 mg, may be repeated up to qid. Severe airway obstruction Up to 40 mg/kg/day under medical supervision. Hivent EM Adult & childn Severe bronchospasm & status asthmaticus Initially 2.5 mg but may be increased to 5 mg, may be repeated up to qid via nebulizer. Hivent Plus Adult Acute attacks 2.5 mL for prompt symptom relief, may increase to 5 mL in severe cases if attack has not been relieved. Maintenance: 2.5 mL every 6-8 hr daily. Childn 2-12 yr 3 drops/kg/dose. Max: 2500 mcg (2.5 mg) of salbutamol every 6-8 hr.

Hypersensitivity. Hivent EM Thyrotoxicosis. Threatened abortion (1st & 2nd trimester). Hivent Plus Hypertrophic obstructive cardiomyopathy or tachyarrhythmia.

CV diseases eg, ischaemic heart disease, arrhythmia or tachycardia, occlusive vascular disorders including arteriosclerosis, HTN or aneurysm. Pregnancy & lactation. Hivent EM Anginal pain in patients w/ angina pectoris; convulsive disorders, hyperthyroidism or DM. Increased susceptibility to digitalis-induced cardiac arrhythmias. Patients taking other sympathomimetic drugs. Not indicated for prevention of premature labor associated w/ toxemia of pregnancy or antepartum hemorrhage. Hivent Plus Paradoxical bronchoconstriction may occur. Can produce clinically significant CV effect. Should not be given in patients w/ close- & narrow-angle glaucoma. Thyrotoxicosis, heart failure & cardiac surgery. Acute MI.

Fine tremor of the hands. Muscle cramps, tension, headache. Hivent EM Tachycardia, palpitations, flushing. Feeling of nervousness. Hivent Plus Peripheral vasodilation. Difficulty in micturition, vomiting, urinary retention & dyspnea. Dryness of mouth w/ difficulty swallowing & talking, thirst & reduced bronchial secretions. Flushing & dryness of skin. Transient bradycardia followed by tachycardia w/ palpitations & arrhythmia.

Effects are antagonized by propranolol or other β-adrenoceptor blocking agents. High doses of corticosteroids may exacerbate metabolic effects of high dose β₂-agonist. Hivent EM May enhance effects w/ aminophylline or xanthine. May increase susceptibility to digitalis-induced cardiac arrhythmias. Hivent Plus May enhance ipratropium effects w/ anticholinergic drugs. Sympathomimetics may antagonize the effects of anti-hypertensive agents. Potentiated sympathomimetic activities of β-agonists w/ MAOIs. Acute worsening of hypokalemia w/ non-K sparing diuretics eg, loop & thiazide diuretics.

Antiasthmatic & COPD Preparations

R03AL02 - salbutamol and ipratropium bromide ; Belongs to the class of combination of adrenergics with anticholinergics, that may also include a corticosteroid. Used in the treatment of obstructive airway diseases.
R03AC02 - salbutamol ; Belongs to the class of adrenergic inhalants, selective beta-2-adrenoreceptor agonists. Used in the treatment of obstructive airway diseases.

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